Autoimuna tireoidna stimulacija - povodom 60 godina otkrica LATS-a
نویسندگان
چکیده
منابع مشابه
Effects of long-acting thyroid stimulator (LATS) and LATS protector on human thyroid adenyl cyclase activity.
The long-acting thyroid stimulator (LATS) has been thought to be responsible for the hyperthyroidism of Graves's disease. It is detected by its effect on the mouse thyroid gland but cannot be found in all patients with hyperthyroidism. In an attempt to clarify the problem of LATS-negative hyperthyroidism, serum was obtained from untreated patients and its effect in vitro on human thyroid tissue...
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The Ras Association Domain Family 1A (RASSF1A) gene is one of the most frequently silenced genes in human cancer. RASSF1A has been shown to interact with the proapoptotic kinase MST1. Recent work in Drosophila has led to the discovery of a new tumor-suppressor pathway involving the Drosophila MST1 and MST2 ortholog, Hippo, as well as the Lats/Warts serine/threonine kinase and a protein named Sa...
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The Yes-associated protein (YAP) transcription coactivator is a key regulator of organ size and a candidate human oncogene. YAP is inhibited by the Hippo pathway kinase cascade, at least in part via phosphorylation of Ser 127, which results in YAP 14-3-3 binding and cytoplasmic retention. Here we report that YAP is phosphorylated by Lats on all of the five consensus HXRXXS motifs. Phosphorylati...
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The Hippo pathway regulates tissue growth and organ size, and inactivation contributes to cancer. Signals flow through Mst/Lats kinases, which phosphorylate and promote cytoplasmic localization of the transcriptional regulators Yap and Taz to inhibit transcription. Here, we identify the multidomain-containing guanine nucleotide exchange factor (GEF) Arhgef7, or βPix, as a positive Hippo pathway...
متن کاملLATS activity, exophthalmos and digital clubbing associated with myxoedema.
RIACH, I.C.F. (1966) The Stella Index-A relationship between the area of the sella turcica and the lateral area of the skull. Brit. J. Radiol. 39, 824. SMrrH, D.W., BLiZZARD, R.M. & WILKINS, L. (1957) The mental prognosis in hypothyroidism of infancy and childhood. Pediatrics, 19, 1011. VON HARNACK, G.A. (1953) Eineiige Zwillinge mit diskordanter Hypothyreose. Arch. Kinderheilk, 146, 60. VON HA...
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ژورنال
عنوان ژورنال: Medicinski glasnik Specijalna bolnica za bolesti stitaste zlezde i bolesti metabolizma Zlatibor
سال: 2015
ISSN: 1452-0923
DOI: 10.5937/medgla1559007p